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カレントテラピー　33-1　サンプル

14 Current Therapy 2015 Vol.33 No.114参考文献1）Mueckler M, Thorens B：The SLC2（GLUT）family ofmembrane transporters. Mol Aspects Med 34：121-138, 20132）Wright EM：Glucose transport families SLC5 and SLC50.Mol Aspects Med 34：183-196, 20133）Wright EM, Loo DD, Hirayama BA：Biology of human sodiumglucose transporters. Physiol Rev 91：733-794, 20114）Chen LH, Leung PS：Inhibition of the sodium glucose cotransporter-2：its beneficial action and potential combinationtherapy for type 2 diabetes mellitus. Diabetes Obes Metab15：392-402, 20135）Bonner C, et al：The glucose transporter SGLT2 is expressedin human pancreatic alpha cells and is required for propercontrol of glucagon secretion in type 2 diabetes. The AmericanDiabetes Association’s 74th Scientific Sessions, 20146）Cefalu WT：Paradoxical insights into whole body metabolicadaptations following SGLT2 inhibition. J Clin Invest 124：485-487, 20147）金井好克：栄養素トランスポーター：その研究の進展と今後の課題，栄養・食品機能とトランスポーター．竹谷　豊，薩　秀夫，伊藤美紀子ほか編．建帛社，東京，20118）Turk E, Zabel B, Mundlos S, et al：Glucose/galactose malabsorptioncaused by a defect in the Na＋/glucose cotransporter.Nature 350：354-356, 19919）Abdul-Ghani MA, DeFronzo RA, Norton L：Novel hypothesisto explain why SGLT2 inhibitors inhibit only 30-50％ of filteredglucose load in humans. Diabetes 62：3324-3328, 201310）van den Heuvel LP, Assink K, Willemsen M, et al：Autosomalrecessive renal glucosuria attributable to a mutation inthe sodium glucose cotransporter（SGLT2）. Hum Genet111：544-547, 200211）Kanai Y, Lee WS, You G, et al：The human kidney low affinityNa＋/glucose cotransporter SGLT2. Delineation of themajor renal reabsorptive mechanism for D-glucose. J ClinInvest 93：397-404, 199412）Rahmoune H, Thompson PW, Ward JM, et al：Glucose transportersin human renal proximal tubular cells isolated fromthe urine of patients with non-insulin-dependent diabetes.Diabetes 54：3427-3434, 200513）Tabatabai NM, Sharma M, Blumenthal SS, et al：Enhancedexpressions of sodium-glucose cotransporters in the kidneysof diabetic Zucker rats. Diabetes Res Clin Pract 83：e27-e30,200914）DeFronzo RA, Hompesch M, Kasichayanula S, et al：Characterizationof renal glucose reabsorption in response to dapagliflozinin healthy subjects and subjects with type 2 diabetes.Diabetes Care 36：3169-3176, 201315）Rossetti L, Shulman GI, Zawalich W, et al：Effect of chronichyperglycemia on in vivo insulin secretion in partially pancreatectomizedrats. J Clin Invest 80：1037-1044, 198716）Rossetti L, Smith D, Shulman GI, et al：Correction of hyperglycemiawith phlorizin normalizes tissue sensitivity to insulinin diabetic rats. J Clin Invest 79：1510-1515, 198717）Bailey CJ：Renal glucose reabsorption inhibitors to treat diabetes.Trends Pharmacol Sci 32：63-71, 2011