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ease Education Program -IFCC Working Group on Standardizationof Albumin in Urine：Current issues in measurementand reporting of urinary albumin excretion. Clin Chem 55：24 -38, 20093）Stehouwer CD, Sm....

ease Education Program -IFCC Working Group on Standardizationof Albumin in Urine：Current issues in measurementand reporting of urinary albumin excretion. Clin Chem 55：24 -38, 20093）Stehouwer CD, Smulders YM：Microalbuminuria and riskfor cardiovascular disease：Analysis of potential mechanisms.J Am Soc Nephrol 17：2106-2111, 20064）Hillege HL, Fidler V, Diercks GF, et al；Prevention of Renaland Vascular End Stage Disease（PREVEND）StudyGroup：Urinary albumin excretion predicts cardiovascularand noncardiovascular mortality in general population. Circulation106：1777 -1782, 20025）Parikh NI, Hwang SJ, Larson MG, et al：Chronic kidney diseaseas a predictor of cardiovascular disease（from theFramingham Heart Study）. Am J Cardiol 102：47-53, 20086）Konta T, Hao Z, Abiko H, et al：Prevalence and risk factoranalysis of microalbuminuria in Japanese general population：theTakahata study. Kidney Int 70：751 -756, 20067）Gerstein HC, Mann JF, Yi Q, et al；HOPE Study Investigators：Albuminuriaand risk of cardiovascular events, death,and heart failure in diabetic and nondiabetic individuals.JAMA 286：421 -426, 20018）Ibsen H, Olsen MH, Wachtell K, et al：Reduction in albuminuriatranslates to reduction in cardiovascular events inhypertensive patients：losartan intervention for endpointreduction in hypertension study. Hypertension 45：198 -202,20059）Matsushita K, van der Velde M, Astor BC, et al；ChronicKidney Disease Prognosis Consortium：Association of estimatedglomerular filtration rate and albuminuria with allcauseand cardiovascular mortality in general populationcohorts：a collaborative meta -analysis. Lancet 375：2073 -2081, 201010）Verhave JC, Gansevoort RT, Hillege HL, et al；PREVENDStudy Group：An elevated urinary albumin excretion predictsde novo development of renal function impairment inthe general population. Kidney Int Suppl：S18-21, 200411）Lemley KV, Blouch K, Abdullah I, et al：Glomerular permselectivityat the onset of nephropathy in type 2 diabetes mellitus.J Am Soc Nephrol 11：2095 -2105, 200012）Hamano K, Nitta A, Ohtake T, et al：Associations of renalvascular resistance with albuminuria and other macroangiopathyin type 2 diabetic patients. Diabetes Care 31：1853 -1857, 200813）Deen WM：What determines glomerular capillary permeability?J Clin Invest 114：1412-1414, 200414）Haraldsson B, Sorensson J：Why do we not all have proteinuria?An update of our current understanding of the glomerularbarrier. News Physiol Sci 19：7-10, 200415）van den Hoven MJ, Rops AL, Bakker MA, et al：Increasedexpression of heparanase in overt diabetic nephropathy. KidneyInt 70：2100 -2108, 200616）Satoh M, Fujimoto S, Haruna Y, et al：NAD（P）H oxidaseand uncoupled nitric oxide synthase are major sources of glomerularsuperoxide in rats with experimental diabeticnephropathy. Am J Physiol Renal Physiol 288：F1144 -1152,200517）Satoh M, Fujimoto S, Arakawa S, et al：AngiotensinⅡtype1 receptor blocker ameliorates uncoupled endothelial nitricoxide synthase in rats with experimental diabetic nephropathy.Nephrol Dial Transplant 23：3806-3813, 200818）Matsumoto Y, Ueda S, Yamagishi S, et al：Dimethylargininedimethylaminohydrolase prevents progression of renal dysfunctionby inhibiting loss of peritubular capillaries and tubulointerstitialfibrosis in a rat model of chronic kidney disease.J Am Soc Nephrol 18：1525 -1533, 200719）Kuwabara A, Satoh M, Tomita N, et al：Deterioration of glomerularendothelial surface layer induced by oxidative stressis implicated in altered permeability of macromolecules inZucker fatty rats. Diabetologia 53：2056-2065, 201020）Nakagawa T, Sato W, Glushakova O, et al：Diabetic endothelialnitric oxide synthase knockout mice develop advanceddiabetic nephropathy. J Am Soc Nephrol 18：539-550, 200714Current Therapy 2012 Vol.30 No.8742