カレントテラピー　30-4サンプル page 16/28

このページは カレントテラピー　30-4サンプル の電子ブックに掲載されている16ページの概要です。
秒後に電子ブックの対象ページへ移動します。
「電子ブックを開く」をクリックすると今すぐ対象ページへ移動します。

概要：
Ⅶおわりに脳βアミロイドーシスの個体間伝播について，主に動物を用いた研究結果を中心に概説した．動物実験では，脳βアミロイドーシスも個体間伝播が可能であるという報告が積み上げられてきている．プリオン病の....

Ⅶおわりに脳βアミロイドーシスの個体間伝播について，主に動物を用いた研究結果を中心に概説した．動物実験では，脳βアミロイドーシスも個体間伝播が可能であるという報告が積み上げられてきている．プリオン病の教訓から考えると，ADについても医療行為や食品によるヒトでの伝播の可能性が問題となるが，現在までに伝播を裏づけるデータはない．今後，詳細な症例検討や疫学研究などを注意深く行っていく必要がある．参考文献1）Will RG, Ironside JW, Zeidler M, et al：A new variant ofCreutzfeldt-Jakob disease in the UK. Lancet 347：921 -925,19962）B r o w n P , B r a n d e l J P , P r e e c e M , e t a l：I a t r o g e n i cCreutzfeldt-Jakob disease：the waning of an era. Neurology67：389 -393, 20063）Prusiner SB：Prions. Proc Natl Acad Sci U S A 95：13363 -13383, 19984）Liu H, Farr-Jones S, Ulyanov NB, et al：Solution structure ofSyrian hamster prion protein rPrP（90-231）. Biochemistry38：5362-5377, 19995）Pan KM, Baldwin M, Nguyen J, et al：Conversion of alphahelicesinto beta-sheets features in the formation of the scrapieprion proteins. Proc Natl Acad Sci U S A 90：10962 -10966, 19936）Riek R, Hornemann S, Wider G, et al：NMR structure of themouse prion protein domain PrP（121 -321）. Nature 382：180-182, 19967）McKinley MP, Meyer RK, Kenaga L, et al：Scrapie prion rodformation in vitro requires both detergent extraction andlimited proteolysis. J Virol 65：1340-1351, 19918）Soto C：Unfolding the role of protein misfolding in neurodegenerativediseases. Nat Rev Neurosci 4：49-60, 20039）Brundin P, Melki R, Kopito R：Prion -like transmission ofprotein aggregates in neurodegenerative diseases. Nat RevMol Cell Biol 11：301 -307, 201010）Frost B, Diamond MI：Prion -like mechanisms in neurodegenerativediseases. Nat Rev Neurosci 11：155 -159, 201011）Jucker M, Walker LC：Pathogenic protein seeding inAlzheimer disease and other neurodegenerative disorders.Ann Neurol 70：532 -540, 201112）Hardy J, Selkoe DJ：The amyloid hypothesis of Alzheimer’sdisease：progress and problems on the road to therapeutics.Science 297：353 -356, 200213）Woodruff-Pak DS：Animal models of Alzheimer’s disease：therapeutic implications. J Alzheimers Dis 15：507-521, 200814）Goudsmit J, Morrow CH, Asher DM, et al：Evidence for andagainst the transmissibility of Alzheimer disease. Neurology30：945 -950, 198015）Manuelidis EE, de Figueiredo JM, Kim JH, et al：Transmissionstudies from blood of Alzheimer disease patients and healthyrelatives. Proc Natl Acad Sci U S A 85：4898-4901, 198816）Godec MS, Asher DM, Kozachuk WE, et al：Blood buffy coatfrom Alzheimer’s disease patients and their relatives doesnot transmit spongiform encephalopathy to hamsters. Neurology44：1111-1115, 199417）Kane MD, Lipinski WJ, Callahan MJ, et al：Evidence forseeding of beta -amyloid by intracerebral infusion ofAlzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. J Neurosci 20：3606-3611, 200018）Meyer -Luehmann M, Coomaraswamy J, Bolmont T, et al：Exogenous induction of cerebral beta -amyloidogenesis isgoverned by agent and host. Science 313：1781 -1784, 200619）Bernoulli C, Siegfried J, Baumgartner G, et al：Danger ofaccidental person -to -person transmission of Creutzfeldt -Jakob disease by surgery. Lancet 1：478-479, 197720）Gibbs CJ Jr, Asher DM, Kobrine A, et al：Transmission ofCreutzfeldt -Jakob disease to a chimpanzee by electrodescontaminated during neurosurgery. J Neurol Neurosurg Psychiatry57：757 -758, 199421）Eisele YS, Bolmont T, Heikenwalder M, et al：Induction ofcerebral beta -amyloidosis：intracerebral versus systemicAbeta inoculation. Proc Natl Acad Sci U S A 106：12926-12931, 200922）Eisele YS, Obermuller U, Heilbronner G, et al：Peripherallyapplied A｛beta｝-containing inoculates induce cerebral｛beta｝-amyloidosis. Science 330：980-982, 201023）Hamaguchi T, Eisele YS, Varvel NH, et al：The presence ofAβseeds, and not age per se, is critical to the initiation of Aβdeposition in the brain. Acta Neuropathologica 123：31 -37, 201224）Morales R, Duran-Aniotz C, Castilla J, et al：De novo inductionof amyloid -βdeposition in vivo. Mol Psychiatry 2011［Epub ahead of print］25）Ridley RM, Baker HF, Windle CP, et al：Very long termstudies of the seeding of beta-amyloidosis in primates. Journalof Neural Transmission 113：1243-1251, 200626）Rosen RF, Fritz JJ, Dooyema J, et al：Exogenous seeding ofcerebralβ-amyloid deposition inβAPP-transgenic rats. JNeurochem 2011［Epub ahead of print］27）Bohnen NI, Warner MA, Kokmen E, et al：Prior blood transfusionsand Alzheimer’s disease. Neurology 44：1159-1160, 199428）O’Meara ES, Kukull WA, Schellenberg GD, et al：Alzheimer’s disease and history of blood transfusion by apolipoprotein -E genotype. Neuroepidemiology 16：86-93, 199729）Kokmen E, Beard CM, O’Brien PC, et al：Epidemiology ofdementia in Rochester, Minnesota. Mayo Clin Proc 71：275 -282, 199630）Zuo C, Zuo Z：Spine Surgery under general anesthesia maynot increase the risk of Alzheimer’s disease. Dement GeriatrCogn Disord 29：233-239, 201031）Knopman DS, Petersen RC, Cha RH, et al：Coronary arterybypass grafting is not a risk factor for dementia or Alzheimerdisease. Neurology 65：986-990, 200532）Gasparini M, Vanacore N, Schiaffini C, et al：A case -controlstudy on Alzheimer’s disease and exposure to anesthesia.Neurol Sci 23：11-14, 200256Current Therapy 2012 Vol.30 No.4340