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概要：
botic therapy increases severe bleeding events in patientswith stroke and cardiovascular disease：a prospective, multicenter,observational study. Stroke 39：1740-1745, 200815）Diener HC, Bogouslavsky ....

botic therapy increases severe bleeding events in patientswith stroke and cardiovascular disease：a prospective, multicenter,observational study. Stroke 39：1740-1745, 200815）Diener HC, Bogouslavsky J, Brass LM, et al；MATCH investigators：Aspirinand clopidogrel compared with clopidogrelalone after recent ischaemic stroke or transient ischaemicattack in high -risk patients（MATCH）：randomized, double-blind,placebo-controlled trial. Lancet 364：331 -337, 200416）Bhatt DL, Fox KA, Hacke W, et al；CHARISMA Investigators：Clopidogreland aspirin versus aspirin alone for theprevention of atherothrombotic events. N Engl J Med 354：1706-1717, 200617）Diener HC, Cunha L, Forbes C, et al：European Stroke PreventionStudy. 2. Dipyridamole and acetylsalicylic acid in thesecondary prevention of stroke. J Neurol Sci 143：1 -13,199618）Halkes PH, van Gijn J, Kappelle LJ, et al；ESPRIT StudyGroup：Aspirin plus dipyridamole versus aspirin alone aftercerebral ischaemia of arterial origin（ESPRIT）：randomisedcontrolled trial. Lancet 367：1665-1673, 200619）Sacco RL, Diener HC, Yusuf S, et al；PRoFESS StudyGroup：Aspirin and extended -release dipyridamole versusclopidogrel for recurrent stroke. N Engl J Med 359：1238-1251, 200820）Uchiyama S, Ikeda Y, Urano Y, et al：The Japaneseaggrenox（extended -release dipyridamole plus aspirin）stroke prevention versus aspirin programme（JASAP）study：a randomized, double-blind, controlled trial. CerebrovascDis 31：601-613, 201121）Kwon SU, Cho YJ, Koo JS, et al：Cilostazol prevents the progressionof the symptomatic intracranial arterial stenosis：the multicenter double -blind placebo -controlled trial of cilostazolin symptomatic intracranial arterial stenosis. Stroke36：782-786, 200522）Kwon SU, Hong KS, Kang DW, et al：Efficacy and safety ofcombination antiplatelet therapies in patients with symptomaticintracranial atherosclerotic stenosis. Stroke 42：2883 -2890, 201142Current Therapy 2012 Vol.30 No.111142