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参考文献1）Fujita T, Henry WL, Bartter FC, et al：Factors influencingblood pressure in salt -sensitive patients with hypertension.Am J Med 69：334-344, 19802）Huang M, Hester RL, Coleman TG, et al：De....

参考文献1）Fujita T, Henry WL, Bartter FC, et al：Factors influencingblood pressure in salt -sensitive patients with hypertension.Am J Med 69：334-344, 19802）Huang M, Hester RL, Coleman TG, et al：Development ofhypertension in animals with reduced total peripheral resistance.Hypertension 20：828-833, 19923）Dahl LK, Heine M, Thompson K：Genetic influence of thekidneys on blood pressure. Evidence from chronic renalhomografts in rats with opposite predispositions to hypertension.Circ Res 40：94 -101, 19744）Hall JE, Brands MW, Henegar JR：AngiotensinⅡand long -term arterial pressure regulation：the overriding dominanceof the kidney. J Am Soc Nephrol 10：S258-265, 19995）Rocchini AP, Key J, Bondie D, et al：The effect of weightloss on the sensitivity of blood pressure to sodium in obeseadolescents. N Engl J Med 321：580 -585, 19896）Nagase M, Yoshida S, Shibata S, et al：Enhanced aldosteronesignaling in the early nephropathy of rats with metabolicsyndrome：possible contribution of fat -derived factors. J AmSoc Nephrol 17：3438-3446, 20067）Goodfriend TL, Ball DL, Egan BM, et al：Epoxy -keto derivativeof linoleic acid stimulates aldosterone secretion.Hypertension 43：358 -363, 20048）Jeon JH, Kim KY, Kim JH, et al：A novel adipokine CTRP1stimulates aldosterone production. FASEB J 22：1502?1511,20089）S t a m l e r J , R o s e G , E l l i o t t P , e t a l：F i n d i n g s o f t h eInternational Cooperative INTERSALT Study. Hypertension17（1 Suppl）：Ⅰ9 -15, 199110）Geleijnse JM, Hofman A, Witteman JC, et al：Long -termeffects of neonatal sodium restriction on blood pressure.Hypertension 29：913-917, 199711）Kawarazaki H, Ando K, Nagae A, et al：Mineralocorticoidreceptor activation contributes to salt -induced hypertensionand renal injury in prepubertal Dahl salt -sensitive rats.Nephrol Dial Transplant 25：2879-2889, 201012）Kawarazaki H, Ando K, Fujita M, et al：Mineralocorticoidreceptor activation：a major contributor to salt -inducedrenal injury and hypertension in young rats. Am J PhysiolRenal Physiol 300：F1402-1409, 201113）Shibata S, Mu S, Kawarazaki H, et al：Rac1 GTPase inrodent kidneys is essential for salt -sensitive hypertensionvia a mineralocorticoid receptor-dependent pathway. J ClinInvest 121：3233-3243, 201114）Shibata S, Nagase M, Yoshida S, et al：Modification of mineralocorticoidreceptor function by Rac1 GTPase：implicationin proteinuric kidney disease. Nat Med 14：1370-1376, 200815）Fujita T, Ando K, Ogata E：Systemic and regional hemodynamicsin patients with salt - sensitive hypertension.Hypertension 16：235-244, 199016）Ono A, Kuwaki T, Kumada M, et al：Differential centralmodulation of the baroreflex by salt loading in normotensiveand spontaneously hypertensive rats. Hypertension 29：808 -814, 199717）Fujita M, Kuwaki T, Ando K, et al：Sympatho -inhibitoryaction of endogenous adrenomedullin through inhibition ofoxidative stress in the brain. Hypertension 5：1165 -1172,200518）Nagae A, Fujita M, Kawarazaki H, et al：Sympathoexcitationby oxidative stress in the brain mediates arterial pressureelevation in obesity -induced hypertension. Circulation 119：978 -986, 200919）Mu S, Shimosawa T, Ogura S, et al：Epigenetic modulationof the renalβ-adrenergic-WNK4 pathway in salt-sensitivehypertension. Nat Med 17：573-580, 201112Current Therapy 2012 Vol.30 No.112